| Identification | Back Directory | [Name]
Tricyclo[3.3.1.13,7]decan-1-amine, 3-(2-fluoroethyl)-, hydrochloride (1:1) | [CAS]
1639210-25-5 | [Synonyms]
Fluoroethylnormemantine hydrochloride
Tricyclo[3.3.1.13,7]decan-1-amine, 3-(2-fluoroethyl)-, hydrochloride (1:1) | [Molecular Formula]
C12H21ClFN | [MOL File]
1639210-25-5.mol | [Molecular Weight]
233.76 |
| Hazard Information | Back Directory | [Uses]
3-?(2-Fluoroethyl)?-tricyclo[3.3.1.13,?7]?decan-?1-?amine Hydrochloride is a N-methyl-D-aspartate (NMDA) receptor antagonist used against stress-induced affective disorders. | [in vivo]
Fluoroethylnormemantine (0.1-10 mg/kg; a single i.p.) shows anti-amnesic effects on Aβ?25-35-induced learning impairments in mice[1].
Fluoroethylnormemantine (0.1-10 mg/kg; i.p. once daily for 7 days) attenuates Aβ?25-35-induced behavioral deficits, neuroinflammation, oxidative stress, apoptosis, and cell loss in mice[1].
Fluoroethylnormemantine (1-20 mg/kg; a single injection) decreases behavioral despair in the forced swim test (FST) and reduces fear behavior in the cued fear conditioning (FC) and extinction training in rats[2]. | Animal Model: | Male Swiss CD-1 mice (7-9 weeks) were injected with Aβ25-35[1] | | Dosage: | 0.1, 0.3, 1, 3, 10 mg/kg | | Administration: | I.p. 30 minutes before the behavioral tests | | Result: | Attenuated Aβ?25-35-induced spontaneous alternation deficit, passive avoidance deficit, and novel object exploration deficit. |
| [IC 50]
NMDA Receptor |
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