| Identification | Back Directory | [Name]
L-Lysine, N6-(L-prolyl-L-alanyl-L-lysyl)-N2-[[(3S)-1,2,3,4-tetrahydro-6,7-dihydroxy-1,1-dimethyl-3-isoquinolinyl]carbonyl]- | [CAS]
1639303-73-3 | [Synonyms]
Odatroltide
DHDMIQK(KAP)
L-Lysine, N6-(L-prolyl-L-alanyl-L-lysyl)-N2-[[(3S)-1,2,3,4-tetrahydro-6,7-dihydroxy-1,1-dimethyl-3-isoquinolinyl]carbonyl]- | [Molecular Formula]
C32H51N7O8 | [MOL File]
1639303-73-3.mol | [Molecular Weight]
661.79 |
| Hazard Information | Back Directory | [Uses]
Odatroltide (LT3001; DHDMIQK(KAP)) is a P-selectin inhibitor. Odatroltide is a peptide molecule comprising a tripeptide Pro-Ala-Lys (PAK) and an (S)-6,7-dihydroxy-1,1-dimethyl-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid domain. Odatroltide can restore cerebral blood flow, scavenge free radicals, and inhibit leukocyte migration. Odatroltide possesses thrombolytic and anti-thrombotic activities[1][2]. | [in vivo]
Odatroltide (0.01 nmol/kg) lyses the thrombus and inhibits thrombosis with a minimal[1]. | [References]
[1] Feng Q, et al. DHDMIQK(KAP): a novel nano-delivery system of dihydroxyl-tetrahydro-isoquinoline-3-carboxylic acid and KPAK towards the thrombus. J Mater Chem B. 2016;4(36):5991-6003. DOI:10.1039/c6tb00874g |
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