| Identification | Back Directory | [Name]
Pyrazolo[1,5-a]pyrazin-4(5H)-one, 6,7-dihydro-7-methyl-3-(2-methyl-4-pyridinyl)-5-[4-(trifluoromethyl)phenyl]-, (7S)- | [CAS]
1639898-35-3 | [Synonyms]
mGluR2 modulator 5
Pyrazolo[1,5-a]pyrazin-4(5H)-one, 6,7-dihydro-7-methyl-3-(2-methyl-4-pyridinyl)-5-[4-(trifluoromethyl)phenyl]-, (7S)- | [Molecular Formula]
C20H17F3N4O | [MOL File]
1639898-35-3.mol | [Molecular Weight]
386.37 |
| Hazard Information | Back Directory | [Uses]
mGluR2 modulator 5 (Compound 11) is an orally active, selective mGluR2 negative allosteric modulator with an IC50 of 8.9 nM. Pharmacokinetic studies in rats show that mGluR2 modulator 5 can effectively cross the blood-brain barrier. It can modulate cognitive and neurological functions in mood disorders and is suitable for research in the field of neurodegenerative diseases[1]. | [IC 50]
mGluR2: 8.9 nM (IC50) | [References]
[1] Alonso de Diego SA, et al. Discovery of 6,7-Dihydropyrazolo[1,5-a]pyrazin-4(5H)-one Derivatives as mGluR2 Negative Allosteric Modulators with In Vivo Activity in a Rodent's Model of Cognition. J Med Chem. 2024 Sep 12;67(17):15569-15585. DOI:10.1021/acs.jmedchem.4c01227 |
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