| Identification | Back Directory | [Name]
Mc-Val-Ala-PAB-PNP | [CAS]
1639939-40-4 | [Synonyms]
Mc-Val-Ala-PAB-PNP
L-Alaninamide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenyl]- | [Molecular Formula]
C32H37N5O10 | [MDL Number]
MFCD32220341 | [MOL File]
1639939-40-4.mol | [Molecular Weight]
651.66 |
| Chemical Properties | Back Directory | [Boiling point ]
946.4±65.0 °C(Predicted) | [density ]
1.323±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
13.31±0.70(Predicted) | [color ]
White to off-white | [InChIKey]
VMOQJVBAOUFRSX-LGGPFLRQSA-N | [SMILES]
C(N)(=O)[C@H](C)N(C(=O)[C@H](C(C)C)NC(=O)CCCCCN1C(=O)C=CC1=O)C1=CC=C(COC(OC2=CC=C([N+]([O-])=O)C=C2)=O)C=C1 |
| Hazard Information | Back Directory | [Uses]
Mc-Val-Ala-PAB-PNP is a cleavable ADC linker for the synthesis of antibody-drug conjugates (ADCs). Cryptophycin-55 (CR55) can be conjugated to the model antibody trastuzumab (an anti-HER2 antibody drug approved by the FDA for the treatment of breast cancer) through the linker of Mc-NHS and Mc-Val-Cit-PAB-PNP to prepare trastuzumab-CR55 conjugates. These conjugates exhibit potent cytotoxicity in HER2-positive tumor cell lines, with IC50 values at low nanomolar levels (0.58-1.19 nM)[1]. | [Biological Activity]
MC-Val-Ala-PAB-PNP is a cleavable ADC linker that can be used to synthesize antibody-drug conjugates (ADCs). | [in vitro]
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. | [target]
| [IC 50]
Protease Cleavable Linker; Cleavable Linker | [References]
[1] QINHUAI LAI . Cryptophycin-55/52 based antibody-drug conjugates: Synthesis, efficacy, and mode of action studies[J]. European Journal of Medicinal Chemistry, 2020. DOI:10.1016/j.ejmech.2020.112364. |
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