| Identification | Back Directory | [Name]
Si306 | [CAS]
1640012-88-9 | [Synonyms]
Si306
1H-Pyrazolo[3,4-d]pyrimidin-4-amine, N-(3-bromophenyl)-1-(2-chloro-2-phenylethyl)-6-[[2-(4-morpholinyl)ethyl]thio]- | [Molecular Formula]
C25H26BrClN6OS | [MOL File]
1640012-88-9.mol | [Molecular Weight]
573.94 |
| Chemical Properties | Back Directory | [Boiling point ]
733.451±70.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.529±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [pka]
6.163±0.10(predicted) |
| Hazard Information | Back Directory | [Uses]
Si306 is a Src inhibitor with antitumor activity. Si306 reduces the phosphorylation of focal adhesion kinase (FAK) and the expression of epidermal growth factor receptor (EGFR), and inhibits the invasion of human glioblastoma (GBM)[1]. | [References]
[1] Ne?ovi?, et al. "Src Inhibitors Pyrazolo [3, 4-d] pyrimidines, Si306 and Pro-Si306, inhibit focal adhesion kinase and suppress human glioblastoma invasion in vitro and in vivo." Cancers 12.6 (2020): 1570. DOI:10.3390/cancers12061570 |
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