| Identification | Back Directory | [Name]
(Rac)-AMG8380 | [CAS]
1641574-26-6 | [Synonyms]
(Rac)-AMG8379
(Rac)-AMG8380
6-Quinolinesulfonamide, 1-(3'-chloro-2,5'-difluoro-5-methoxy[1,1'-biphenyl]-4-yl)-1,2-dihydro-N-3-isoxazolyl-2-oxo- | [Molecular Formula]
C25H16ClF2N3O5S | [MOL File]
1641574-26-6.mol | [Molecular Weight]
543.93 |
| Hazard Information | Back Directory | [Uses]
(Rac)-AMG8379 ((Rac)-AMG8380) is a racemate of AMG8379. AMG8379 is a potent, orally active and selective sulfonamide antagonist of NaV1.7, with IC50s of 8.5 and 18.6 nM for hNaV1.7 and mNaV1.7, respectively [1]. | [IC 50]
hNav1.7: 8.5 nM (IC50); mNav1.7: 18.6 nM (IC50) | [References]
[1] Kornecook TJ, et al. Pharmacologic Characterization of AMG8379, a Potent and Selective Small Molecule Sulfonamide Antagonist of the Voltage-Gated Sodium Channel NaV1.7. J Pharmacol Exp Ther. 2017 Jul;362(1):146-160. DOI:10.1124/jpet.116.239590 |
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