| Identification | Back Directory | [Name]
2-(3-Chloro-4-fluorophenyl)-N-(1-methylethyl)-6-[3-(4-morpholinyl)propoxy]-4-oxo-pyrido[2,3-d]pyrimidine-3(4H)-acetamide hydrochloride | [CAS]
1642187-96-9 | [Synonyms]
TASP 0390325
2-(3-Chloro-4-fluorophenyl)-N-(1-methylethyl)-6-[3-(4-morpholinyl)propoxy]-4-oxo-pyrido[2,3-d]pyrimidine-3(4H)-acetamide hydrochloride | [Molecular Formula]
C25H30Cl2FN5O4 | [MDL Number]
MFCD30742933 | [MOL File]
1642187-96-9.mol | [Molecular Weight]
554.44 |
| Hazard Information | Back Directory | [Uses]
TASP 0390325 is a vasopressin V1B receptor antagonist, which has antidepressant and anxiolytic therapeutic potential. | [in vivo]
TASP0390325 blocks the anterior pituitary V1B receptor in vivo. Oral administration of TASP0390325 antagonized the increase in plasma ACTH levels induced by CRF/dDAVP in rats, indicating that TASP0390325 blocks the anterior pituitary V1B receptor in vivo. TASP0390325 (1 mg/kg) significantly antagonizes CRF/dDAVP-induced plasma ACTH in rats[1].
Oral administration of TASP0390325 also exerts antidepressant effects in two models of depression (a forced swimming test and an olfactory bulbectomy model)[1]. | Animal Model: | Male Sprague-Dawley (SD) rats (211-246 g)[1] | | Dosage: | 0.3 and 1 mg/kg (TASP0390325 is suspended in 0.5% methylcellulose 400) | | Administration: | Oral administration | | Result: | Antagonized the increase in plasma ACTH levels induced by CRF/dDAVP in rats at a dose of 1 mg/kg. In contrast, 0.3 and 1.0 mg/kg itself did not significantly affect basal ACTH levels.
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| [storage]
Store at -20°C |
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