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1642333-05-8

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1642333-05-8 Structure

1642333-05-8 Structure
IdentificationBack Directory
[Name]

22-(tert-Butoxy)-22-oxodocosanoic acid
[CAS]

1642333-05-8
[Synonyms]

22-(tert-Butoxy)-22-oxodocosanoic acid
Docosanedioic acid, 1-(1,1-dimethylethyl) ester
Docosanedioic acid, mono(1,1-dimethylethyl) ester
[Molecular Formula]

C26H50O4
[MDL Number]

MFCD30830215
[MOL File]

1642333-05-8.mol
[Molecular Weight]

426.67
Chemical PropertiesBack Directory
[form ]

powder
[color ]

White
[InChI]

InChI=1S/C26H50O4/c1-26(2,3)30-25(29)23-21-19-17-15-13-11-9-7-5-4-6-8-10-12-14-16-18-20-22-24(27)28/h4-23H2,1-3H3,(H,27,28)
[InChIKey]

OXPWLSZVTHVKQN-UHFFFAOYSA-N
[SMILES]

C(OC(C)(C)C)(=O)CCCCCCCCCCCCCCCCCCCCC(O)=O
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P280-P301+P312-P261
[HS Code ]

2917198090
Hazard InformationBack Directory
[Uses]

22-(tert-Butoxy)-22-oxodocosanoic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 22-(tert-Butoxy)-22-oxodocosanoic acid is also a alkyl chain-based PROTAC linker that can be used in t
[IC 50]

Non-cleavable Linker
[References]

[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. DOI:10.1038/nrd.2016.268
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277
Spectrum DetailBack Directory
[Spectrum Detail]

22-(tert-Butoxy)-22-oxodocosanoic acid(1642333-05-8)1HNMR
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