| Identification | Back Directory | [Name]
22-(tert-Butoxy)-22-oxodocosanoic acid | [CAS]
1642333-05-8 | [Synonyms]
22-(tert-Butoxy)-22-oxodocosanoic acid
Docosanedioic acid, 1-(1,1-dimethylethyl) ester
Docosanedioic acid, mono(1,1-dimethylethyl) ester | [Molecular Formula]
C26H50O4 | [MDL Number]
MFCD30830215 | [MOL File]
1642333-05-8.mol | [Molecular Weight]
426.67 |
| Chemical Properties | Back Directory | [form ]
powder | [color ]
White | [InChI]
InChI=1S/C26H50O4/c1-26(2,3)30-25(29)23-21-19-17-15-13-11-9-7-5-4-6-8-10-12-14-16-18-20-22-24(27)28/h4-23H2,1-3H3,(H,27,28) | [InChIKey]
OXPWLSZVTHVKQN-UHFFFAOYSA-N | [SMILES]
C(OC(C)(C)C)(=O)CCCCCCCCCCCCCCCCCCCCC(O)=O |
| Hazard Information | Back Directory | [Uses]
22-(tert-Butoxy)-22-oxodocosanoic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 22-(tert-Butoxy)-22-oxodocosanoic acid is also a alkyl chain-based PROTAC linker that can be used in t | [IC 50]
Non-cleavable Linker | [References]
[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. DOI:10.1038/nrd.2016.268
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277 |
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