| Identification | Back Directory | [Name]
2,4(1H,3H)-Pyrimidinedione, 6-[4-[[3-(difluoromethoxy)-2-pyridinyl]oxy]-2-methylphenyl]-1,5-dimethyl- | [CAS]
1643462-93-4 | [Synonyms]
PW0464
2,4(1H,3H)-Pyrimidinedione, 6-[4-[[3-(difluoromethoxy)-2-pyridinyl]oxy]-2-methylphenyl]-1,5-dimethyl- | [Molecular Formula]
C19H17F2N3O4 | [MDL Number]
MFCD34474029 | [MOL File]
1643462-93-4.mol | [Molecular Weight]
389.35 |
| Hazard Information | Back Directory | [Uses]
PW0464, a nanomolar potent complete G protein biased ligand, is a noncatechol D1R agonist, with an EC50 of 5.8 nM (Gs-cAMP)[1]. | [References]
[1] Pingyuan Wang, et al. Synthesis and Pharmacological Evaluation of Noncatechol G Protein Biased and Unbiased Dopamine D1 Receptor Agonists. ACS Med Chem Lett DOI:10.1021/acsmedchemlett.9b00050
[2] David R Sibley, et al. Novel Cryo-EM structures of the D1 dopamine receptor unlock its therapeutic potential. Signal Transduct Target Ther. 2021 May 22;6(1):205. DOI:10.1038/s41392-021-00630-3 |
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