| Hazard Information | Back Directory | [Description]
BIBU-1361 dihydrochloride is an inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase that blocks downstream EGFR signaling events such as MAPKK/MAPK activation. | [in vitro]
BIBU (BIBU-1361) caused increased LC3-I to LC3-II conversion and triggered the internalization of EGFR within vacuoles along with its increased co-localization with LC3-II. BIBU caused accumulation of p62 and increased levels of cleaved forms of Beclin-1 in all the cell lines tested._x000D_
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Reference: Mol Carcinog. 2013 Dec;52(12):970-82. https://pubmed.ncbi.nlm.nih.gov/22753156/ | [target]
Selective inhibitor of EGFR-kinase. |
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