ChemicalBook--->CAS DataBase List--->1643957-26-9

1643957-26-9

1643957-26-9 Structure

1643957-26-9 Structure
IdentificationBack Directory
[Name]

Benzyl-PEG3-CH2CO2tBu
[CAS]

1643957-26-9
[Synonyms]

Benzyl-PEG2-CH2-Boc
Benzyl-PEG3-CH2CO2tBu
tert-butyl 2-(2-(2-(benzyloxy)ethoxy)ethoxy)acetate
Acetic acid, 2-[2-[2-(phenylmethoxy)ethoxy]ethoxy]-, 1,1-dimethylethyl ester
[Molecular Formula]

C17H26O5
[MDL Number]

MFCD28122971
[MOL File]

1643957-26-9.mol
[Molecular Weight]

310.39
Chemical PropertiesBack Directory
[storage temp. ]

Storage temp. 2-8°C
[form ]

Liquid
[color ]

Colorless to light yellow
Hazard InformationBack Directory
[Description]

Benzyl-PEG3-CH2CO2tBu is a PEG linker with a benzyl and t-butyl protecting group. Both protecting groups are acid labile. The hydrophilic PEG linker increases the water solubility of the compound in aqueous media.
[Uses]

Benzyl-PEG2-CH2-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
[References]

[1] Ottis P, et al. Assessing Different E3 Ligases for Small Molecule Induced Protein Ubiquitination and Degradation. ACS Chem Biol. 2017 Oct 20;12(10):2570-2578. DOI:10.1021/acschembio.7b00485
Spectrum DetailBack Directory
[Spectrum Detail]

Benzyl-PEG3-CH2CO2tBu(1643957-26-9)1HNMR
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