| Chemical Properties | Back Directory | [Boiling point ]
589.1±48.0 °C(Predicted) | [density ]
1.649±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 125 mg/mL (328.18 mM; Need ultrasonic) | [form ]
Solid | [pka]
5.94±0.50(Predicted) | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Uses]
PDK1-IN-RS2 is a mimic of peptide docking motif (PIFtide) and is a substrate-selective PDK1 inhibitor with a Kd of 9 μM. PDK1-IN-RS2 suppresses the activation of the downstream kinases S6K1 by PDK1[1]. | [References]
[1] Rettenmaier TJ, et al. A small-molecule mimic of a peptide docking motif inhibits the protein kinase PDK1. Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):18590-5. DOI:10.1073/pnas.1415365112 |
|
|