| Identification | Back Directory | [Name]
Pentanamide, 2-amino-N-[3-(difluoromethoxy)-4-(5-oxazolyl)phenyl]-4-methyl-, (2R)- | [CAS]
1644248-18-9 | [Synonyms]
Pentanamide, 2-amino-N-[3-(difluoromethoxy)-4-(5-oxazolyl)phenyl]-4-methyl-, (2R)- | [Molecular Formula]
C16H19F2N3O3 | [MOL File]
1644248-18-9.mol | [Molecular Weight]
339.34 |
| Chemical Properties | Back Directory | [Boiling point ]
474.3±45.0 °C(Predicted) | [density ]
1.258±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
13.03±0.70(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Description]
BMS-911172 is a potent and brain-penetrant, AP2-associated protein kinase 1 (AAK1)-selective inhibitor (IC50 = 12 and 51 nM in enzymes and cells, respectively). BMS-911172 was active in the formalin assay in the Chung mouse model (60 mg/kg s.c.) as well as in the chronic constriction injury-induced thermal hyperalgesia and mechanical allodynia rat model (60 mg/kg). PD marker assay in mice showed a dose-dependent inhibition of phosphorylation of AAK1 substrate mu-2 in the brain. There were no motor side effects at the doses tested. BMS-911172 may be useful for the treatment of neuropathic pain | [Uses]
BMS-911172 is an adaptor associated kinase 1 (AAK1 kinase) inhibitor (IC50 = 35 nM). | [References]
[1] Hartz RA, et al. Aryl amide kinase inhibitors. WO2015006100A1. |
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