| Chemical Properties | Back Directory | [Boiling point ]
639.3±55.0 °C(Predicted) | [density ]
1.527±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 62.5 mg/mL (156.17 mM) | [form ]
Solid | [pka]
6.35±0.40(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
GW406108X is a specific Kif15 (Kinesin-12) inhibitor with an IC50 of 0.82 uM in ATPase assays. GW406108X, a potent autophagy inhibitor, shows ATP competitive inhibition against ULK1 with a pIC50 of 6.37 (427 nM). GW406108X inhibits ULK1 kinase activity and blocks autophagic flux, without affecting the upstream signaling kinases mTORC1 and AMPK[1][2]. | [References]
[1] Zachari M, et al. The identification and characterisation of autophagy inhibitors from the published kinase inhibitor sets. Biochem J. 2020;477(4):801-814. DOI:10.1042/BCJ20190846
[2] Dumas ME, et al. Dual inhibition of Kif15 by oxindole and quinazolinedione chemical probes. Bioorg Med Chem Lett. 2019;29(2):148-154. DOI:10.1016/j.bmcl.2018.12.008 |
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| Company Name: |
yimo organism
|
| Tel: |
15915870272; 15915870272 |
| Website: |
https://www.yimobio.com |
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