| Identification | Back Directory | [Name]
1H-Pyrazole-1-pentanoic acid, 5-(2-chloro-7-ethoxy-3-quinolinyl)-4,5-dihydro-3-(4-iodophenyl)-δ-oxo- | [CAS]
1644626-43-6 | [Synonyms]
TDRL551
TDRL-551
TDRL 551
1H-Pyrazole-1-pentanoic acid, 5-(2-chloro-7-ethoxy-3-quinolinyl)-4,5-dihydro-3-(4-iodophenyl)-δ-oxo- | [Molecular Formula]
C25H23ClIN3O4 | [MOL File]
1644626-43-6.mol | [Molecular Weight]
591.83 |
| Chemical Properties | Back Directory | [Boiling point ]
704.0±70.0 °C(Predicted) | [density ]
1.62±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 62.5 mg/mL (105.60 mM; Need ultrasonic) | [form ]
Solid | [pka]
4.65±0.10(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
TDRL-551 is a potent replication protein A (RPA) inhibitor (IC50=18 μM). TDRL-551 inhibits RPA-DNA interaction and increases the efficacy of Platinum (Pt)-based chemotherapy in lung and ovarian cancer. RPA plays essential roles in both nucleotide excision repair (NER) and homologous recombination (HR), along with its role in DNA replication and DNA damage checkpoint activation[1]. | [Biological Activity]
TDRL-551 is a potent replication protein A (RPA) inhibitor (IC50=18 μM). TDRL-551 inhibits RPA-DNA interaction and increases the efficacy of Platinum (Pt)-based chemotherapy in lung and ovarian cancer. RPA plays essential roles in both nucleotide excision repair (NER) and homologous recombination (HR), along with its role in DNA replication and DNA damage checkpoint activation[1]. | [storage]
Store at -20°C | [References]
[1]. Mishra AK, et al. Chemical inhibitor targeting the replication protein A-DNA interaction increases the efficacy of Pt-based chemotherapy in lung and ovarian cancer. Biochem Pharmacol. 2015;93(1):25-33. |
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