| Identification | Back Directory | [Name]
(S)-N-(5-(3-Fluorobenzyl)-4H-1,2,4-triazol-3-yl)tetrahydrofuran-2-carboxamide | [CAS]
1645486-93-6 | [Synonyms]
(S)-N-(5-(3-Fluorobenzyl)-4H-1,2,4-triazol-3-yl)tetrahydrofuran-2-carboxamide
2-Furancarboxamide, N-[3-[(3-fluorophenyl)methyl]-1H-1,2,4-triazol-5-yl]tetrahydro-, (2S)- | [Molecular Formula]
C14H15FN4O2 | [MOL File]
1645486-93-6.mol | [Molecular Weight]
290.29 |
| Hazard Information | Back Directory | [Uses]
GWP-042 is a potent inhibitor of mycobacterial alanine dehydrogenase (Ald) Rv2780, with the IC50 of 0.21 μM. GWP-042 has antimicrobial activity against M. tuberculosis infection in vivo[1]. | [References]
[1] Cheng Peng, et al. Mycobacterium tuberculosis suppresses host antimicrobial peptides by dehydrogenating L-alanine. Nat Commun. 2024 May 17;15(1):4216.c DOI:10.1038/s41467-024-48588-4 |
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