| Identification | Back Directory | [Name]
UNC2170 Maleate | [CAS]
1648707-58-7 | [Synonyms]
UNC-2170
UNC-2170 HCl
UNC2170 Maleate
UNC2170 trifluoroacetate
3-Bromo-N-(3-(tert-butylamino)propyl)benzamide
Benzamide, 3-bromo-N-[3-[(1,1-dimethylethyl)amino]propyl]- | [Molecular Formula]
C14H21BrN2O | [MDL Number]
MFCD29770818 | [MOL File]
1648707-58-7.mol | [Molecular Weight]
313.23 |
| Chemical Properties | Back Directory | [Boiling point ]
419.6±30.0 °C(Predicted) | [density ]
1.233±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
Soluble in DMSO (up to 40 mg/ml) or in Water (up to 50 mg/ml). | [form ]
solid | [pka]
14.63±0.46(Predicted) | [color ]
White | [Stability:]
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months. | [InChI]
1S/C14H21BrN2O.C2HF3O2/c1-14(2,3)17-9-5-8-16-13(18)11-6-4-7-12(15)10-11;3-2(4,5)1(6)7/h4,6-7,10,17H,5,8-9H2,1-3H3,(H,16,18);(H,6,7) | [InChIKey]
DPAGQICQYYQSQP-UHFFFAOYSA-N | [SMILES]
BrC1=CC=CC(C(NCCCNC(C)(C)C)=O)=C1.FC(F)(C(O)=O)F |
| Safety Data | Back Directory | [WGK Germany ]
WGK 3 | [Storage Class]
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | [Hazard Classifications]
Acute Tox. 3 Oral |
| Hazard Information | Back Directory | [Description]
UNC-2170 (1648707-58-7), identified by screening, was found to be a μM ligand for 53BP1 which also demonstrated at least 17-fold selectivity for 53BP1 over other methyl-lysine binding proteins. The DNA damage response protein 53BP1 utilizes its tandem tudor domain to recognize dimethylated lysine 20 on histone (H4K20me2), a modification associated with double-strand DNA breaks. UNC-2170 functions as a 53BP1 antagonist in cell lysates and suppresses class switch recombination in whole cells, a process requiring a functioning 53BP1 tudor domain.1 | [Uses]
UNC-2170 is a functionally active, fragment-like ligand for 53BP1 (IC50=29 μM; Kd=22 μM). UNC-2170 shows at least 17-fold selectivity for 53BP1 as compared to nine other methyl-lysine (Kme) reader proteins. 53BP1 is a Kme binding protein that plays a central role in DNA Damage Repair (DDR) pathways and is recruited to sites of double-strand breaks (DSB)[1]. | [storage]
4°C, protect from light | [References]
1) Perfetti?et al.?(2015),?Identification of a fragment-like small molecule ligand for the methyl-lysine binding protein 53BP1; ACS Chem. Biol.,?10?1072 |
|
| Company Name: |
Lynnchem
|
| Tel: |
86-(0)29-85992781 17792393971 |
| Website: |
http://www.lynnchem.com/ |
| Company Name: |
Novachemistry
|
| Tel: |
44-20819178-90 02081917890 |
| Website: |
https://www.novachemistry.com/ |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|