| Chemical Properties | Back Directory | [Boiling point ]
407.574±38.00 °C(Press: 760.00 Torr)(predicted) | [density ]
0.961±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [form ]
Oil | [pka]
14.824±0.46(predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
UNC3474 is a small molecule ligand, binding with 53BP1. UNC3474 binds the aromatic methyl-lysine binding cage of 53BP1TT, with a dissociation constant (Kd) of 1.0?±?0.3 μM. UNC3474 inhibits the recruitment of 53BP1 to DSBs by stabilizing a pre-existing autoinhibited state of 53BP1 in cells[1]. | [References]
[1] Cui G, et al. An autoinhibited state of 53BP1 revealed by small molecule antagonists and protein engineering. bioRxiv [Preprint]. 2023 Jul 18:2023.04.20.534960. DOI:10.1101/2023.04.20.534960 |
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