| Identification | Back Directory | [Name]
3,3'-Diamino-4,4'-dihydroxydiphenylmethane | [CAS]
16523-28-7 | [Synonyms]
FMP-API-1
FMP-API-1 >=98% (HPLC)
4,4'-Methylenebis(2-aminophenol)
4,4′-Methylenebis(2-aminophenol)
Phenol, 4,4'-methylenebis[2-amino-
Bis(3-amino-4-hydroxyphenyl)methane
2,2'-diaMino-4,4'-Methanediyl-di-phenol
3,3'-Diamino-4,4'-dihydroxydiphenylmethane
2-amino-4-[(3-amino-4-hydroxy-phenyl)methyl]phenol | [Molecular Formula]
C13H14N2O2 | [MDL Number]
MFCD00443347 | [MOL File]
16523-28-7.mol | [Molecular Weight]
230.26 |
| Chemical Properties | Back Directory | [Melting point ]
220-222 °C (decomp) | [Boiling point ]
372.26°C (rough estimate) | [density ]
1.1372 (rough estimate) | [refractive index ]
1.6450 (estimate) | [storage temp. ]
-20°C | [solubility ]
DMSO: >10mg/mL | [form ]
powder | [pka]
10.24±0.10(Predicted) | [color ]
white to beige | [InChI]
InChI=1S/C13H14N2O2/c14-10-6-8(1-3-12(10)16)5-9-2-4-13(17)11(15)7-9/h1-4,6-7,16-17H,5,14-15H2 | [InChIKey]
KCFVSHSJPIVGCG-UHFFFAOYSA-N | [SMILES]
C(C1=CC=C(O)C(N)=C1)C1=CC=C(O)C(N)=C1 |
| Hazard Information | Back Directory | [Uses]
FMP-API-1 is an A-kinase anchoring protein (AKAP)-PKA interaction inhibitor. FMP-API-1 binds to the allosteric site of PKA R subunits and increases the activity of PKA and AQP2 in PKA-knockout cell lines of renal cortical collecting ducts (mpkCCD cells). FMP-API-1 has the potential for the study of nephrogenic diabetes insipidus (NDI)[1][2]. | [References]
[1] Ando F. Activation of AQP2 water channels by protein kinase A: therapeutic strategies for congenital nephrogenic diabetes insipidus. Clin Exp Nephrol. 2021 Oct;25(10):1051-1056. DOI:10.1007/s10157-021-02108-6
[2] Fumiaki Ando, et al. AKAPs-PKA disruptors increase AQP2 activity independently of vasopressin in a model of nephrogenic diabetes insipidus. Nat Commun. 2018 Apr 12;9(1):1411. DOI:10.1038/s41467-018-03771-2 |
|
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
|