| Identification | Back Directory | [Name]
1-[2-(3,4-DIMETHOXYPHENYL)ETHYL]-4-(3-PHENYLPROPYL)PIPERAZINE | [CAS]
165377-43-5 | [Synonyms]
AGY 94806
CutaMesine
1-(3,4-dimethoxyphenethyl)-4-(3-phenylpropyl)piperazine
1-[2-(3,4-DIMETHOXYPHENYL)ETHYL]-4-(3-PHENYLPROPYL)PIPERAZINE
Piperazine, 1-[2-(3,4-dimethoxyphenyl)ethyl]-4-(3-phenylpropyl)- | [Molecular Formula]
C23H32N2O2 | [MDL Number]
MFCD09842336 | [MOL File]
165377-43-5.mol | [Molecular Weight]
368.51 |
| Chemical Properties | Back Directory | [Boiling point ]
499.2±45.0 °C(Predicted) | [density ]
1.053±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
Soluble in DMSO | [pka]
7.61±0.10(Predicted) |
| Hazard Information | Back Directory | [Uses]
Cutamesine (SA4503; AGY-94806) is a selective sigma 1 receptor(σ1R) agonist; high affinity for the sigma 1 receptor (IC50= 17.4±1.9 nM); 100-fold less affinity for the sigma 2 receptor. | [IC 50]
Sigma 1 Receptor | [storage]
Store at -20°C | [References]
[1] Matsuno K, et al. Binding properties of SA4503, a novel and selective sigma 1 receptor agonist. Eur J Pharmacol. 1996 Jun 13;306(1-3):271-9. DOI:10.1016/0014-2999(96)00201-4
[2] Minabe Y, et al. Acute and chronic administration of the selective sigma1 receptor agonist SA4503 significantly alters the activity of midbrain dopamine neurons in rats: An in vivo electrophysiological study. Synapse. 1999 Aug;33(2):129-40. DOI:10.1002/(SICI)1098-2396(199908)33:23.0.CO;2-E
[3] Ono Y, et al. SA4503, a sigma-1 receptor agonist, suppresses motor neuron damage in in vitro and in vivo amyotrophic lateral sclerosis models. Neurosci Lett. 2014 Jan 24;559:174-8. DOI:10.1016/j.neulet.2013.12.005 |
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