| Identification | Back Directory | [Name]
4-Quinazolinamine, N-(1-ethylpropyl)-6,7,8-trimethoxy-, hydrochloride (1:1) | [CAS]
1655498-17-1 | [Synonyms]
PF04471141
PF-04471141
PF 04471141
PF04471141 HCl
4-Quinazolinamine, N-(1-ethylpropyl)-6,7,8-trimethoxy-, hydrochloride (1:1) | [Molecular Formula]
C16H24ClN3O3 | [MOL File]
1655498-17-1.mol | [Molecular Weight]
341.84 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [solubility ]
DMSO: 20mg/mL, clear | [form ]
powder | [color ]
white to beige | [InChI]
1S/C16H23N3O3.ClH/c1-6-10(7-2)19-16-11-8-12(20-3)14(21-4)15(22-5)13(11)17-9-18-16;/h8-10H,6-7H2,1-5H3,(H,17,18,19);1H | [InChIKey]
QRHFQSUUJMOIHO-UHFFFAOYSA-N | [SMILES]
CCC(CC)NC1=NC=NC2=C(OC)C(OC)=C(OC)C=C21.Cl |
| Hazard Information | Back Directory | [Description]
PF-04471141 is a potent, selective inhibitor of the calcium-activated phosphodiesterase PDE1. (PDE1B IC50 = 35 nM). | [Uses]
PF-04471141 (hydrochloride) is a compound that regulates intracellular cAMP and cGMP concentrations. It is a PDE1 inhibitor and has different effects on different PDE enzymes in regulating intracellular signaling molecule concentrations and cell proliferation in vascular smooth muscle cells. | [References]
[1] Cyclic nucleotide signalling compartmentation by PDEs in cultured vascular smooth muscle cells DOI:10.1111/bph.14651 |
|
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|