| Identification | Back Directory | [Name]
BMS 191095 | [CAS]
166095-21-2 | [Synonyms]
BMS 191095
2H-1-Benzopyran-6-carbonitrile, 4-[(4-chlorophenyl)(1H-imidazol-2-ylmethyl)amino]-3,4-dihydro-3-hydroxy-2,2-dimethyl-, (3R,4S)- | [Molecular Formula]
C22H21ClN4O2 | [MOL File]
166095-21-2.mol | [Molecular Weight]
408.88 |
| Chemical Properties | Back Directory | [Boiling point ]
649.4±55.0 °C(Predicted) | [density ]
1.39±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : ≥ 50 mg/mL (122.29 mM) | [form ]
Solid | [pka]
13.19±0.60(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
BMS-191095 is a selective activator of mitochondrial ATP-sensitive potassium (mitoKATP) channels. BMS-191095 inhibits human platelet aggregation by opening mitochondrial K(ATP) channels[1][2][3]. | [in vivo]
BMS-191095 (2.5 or 25 μg; intraventricular infusion, 30 min/60 min/24 hours before the induction of ischemia, once) reduces neuronal damage in rats with transient focal cerebral ischemia[3]. | Animal Model: | Male Wistar rats with the induction of ischemia induced by middle cerebral artery occlusion (MCAO)[3] | | Dosage: | 2.5 or 25 μg | | Administration: | Intraventricular infusion; 30 min/60 min/24 hours before the induction of ischemia, once | | Result: | Reduced total infarct volume in rats with of pretreat dose of 25 mg and 24 h before MCA. Induced a rapid mitochondrial depolarization.
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| [storage]
Store at -20°C | [References]
[1] Katakam PV, et al. Diversity of mitochondria-dependent dilator mechanisms in vascular smooth muscle of cerebral arteries from normal and insulin-resistant rats. Am J Physiol Heart Circ Physiol. 2014 Aug 15;307(4):H493-503. DOI:10.1152/ajpheart.00091.2014
[2] Cho MR, et al. BMS-191095, a cardioselective mitochondrial K(ATP) opener, inhibits human platelet aggregation by opening mitochondrial K(ATP) channels. Arch Pharm Res. 2005 Jan;28(1):61-7. DOI:10.1007/BF02975137
[3] Mayanagi K, et al. The mitochondrial K(ATP) channel opener BMS-191095 reduces neuronal damage after transient focal cerebral ischemia in rats. J Cereb Blood Flow Metab. 2007 Feb;27(2):348-55. DOI:10.1038/sj.jcbfm.9600345 |
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BOC Sciences
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Musechem
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+1-800-259-7612 |
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www.musechem.com |
| Company Name: |
InvivoChem
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13549236410 |
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https://www.invivochem.cn/ |
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