| Identification | Back Directory | [Name]
L-Ornithinamide, N-[[2-[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]ethoxy]carbonyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]- | [CAS]
1662687-83-3 | [Synonyms]
Mal-PEG2-Val-Cit-PABA
L-Ornithinamide, N-[[2-[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]ethoxy]carbonyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]- | [Molecular Formula]
C27H38N6O9 | [MOL File]
1662687-83-3.mol | [Molecular Weight]
590.63 |
| Chemical Properties | Back Directory | [Boiling point ]
908.5±65.0 °C(Predicted) | [density ]
1.327±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
10.88±0.46(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Mal-PEG2-Val-Cit-PABA is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. | [IC 50]
Protease Cleavable Linker; Cleavable Linker | [References]
[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. DOI:10.1038/nrd.2016.268 |
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