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B. Preparation of 2-(hydroxymethyl)-5-nitrothiophene To a stirred solution of 2-(hydroxymethyl)-5-nitrothiophene (18.8 g, 118 mmol) in dichloromethane (500 mL) at 0 °C were sequentially added triphenylphosphine (31.5 g, 120 mmol) and carbon tetrabromide (39 g, 118 mmol). The reaction mixture was continued to be stirred at 0 °C for 2 hours. After completion of the reaction, the mixture was poured into half-saturated brine and extracted with dichloromethane (3 × 100 mL). The organic layers were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to remove the solvent. The crude product was purified by silica gel column chromatography using 15% ethyl acetate/hexane as eluent to give 2-bromomethyl-5-nitrothiophene (19 g, 61% yield) as a brown oil.