| Identification | Back Directory | [Name]
Urea, N-phenyl-N'-[(3R)-2,3,4,5-tetrahydro-2,4-dioxo-1-phenyl-5-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-1H-1,5-benzodiazepin-3-yl]- | [CAS]
167355-22-8 | [Synonyms]
GV150013
GV-150013
GV 150013
Urea, N-phenyl-N'-[(3R)-2,3,4,5-tetrahydro-2,4-dioxo-1-phenyl-5-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-1H-1,5-benzodiazepin-3-yl]- | [Molecular Formula]
C33H34N4O3 | [MDL Number]
MFCD03106419 | [MOL File]
167355-22-8.mol | [Molecular Weight]
534.65 |
| Hazard Information | Back Directory | [Uses]
GV-150013 is a selective CCK-B receptor antagonist. GV-150013 has sleep aid effect[1]. | [Definition]
ChEBI: GV 150013X is a benzodiazepine. | [in vivo]
GV-150013 (0.5 - 60μg/kg, ip, Once) increase REM sleep and non-REM sleep in old rats model[1]. | Animal Model: | Old rats [2]. | | Dosage: | 0.5 μg/kg, 5μg/kg, 60μg/kg | | Administration: | Intraperitoneal injection, Once | | Result: | The duration of REM sleep and non-REM sleep was longer than that of control. |
| [References]
[1] Crespi F. Cholecystokinin-B (CCK-B) receptor antagonists improve "aged" sleep: a new class of sleep modulators? Methods Find Exp Clin Pharmacol. 1999 Jan-Feb;21(1):31-8. DOI:10.1358/mf.1999.21.1.527016
[2] F.Crespi, et al. Influence of cholecystokinin-B (CCK-B) receptor antagonists on rat electroencephalography (EEG): A new class of sleep modulators? Gaviraghi. Dept of Pharmacology GlaxoWellcome S.p.A., Medicine Research Centre, via A. Fleming, 4, 37135 Verona, Italy |
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