| Identification | Back Directory | [Name]
Terpendole E | [CAS]
167427-23-8 | [Synonyms]
FO 2546L
Terpendole E
Terpendole E >=95% (HPLC)
1-Benzopyrano[5',6':6,7]indeno[1,2-b]isobenzofuro[5,6-e]indole-2-methanol, 3,4,4a,4b,5,6,6a,7,12,12b,12c,13,14,14a-tetradecahydro-4-hydroxy-α,α,4a,12b,12c-pentamethyl-, (2S,4R,4aR,4bR,6aS,12bS,12cS,14aS)- | [Molecular Formula]
C28H39NO3 | [MDL Number]
MFCD28346948 | [MOL File]
167427-23-8.mol | [Molecular Weight]
437.61 |
| Chemical Properties | Back Directory | [Boiling point ]
597.1±50.0 °C(Predicted) | [density ]
1.194±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMSO: 10mg/mL, clear | [form ]
powder | [pka]
14.45±0.70(Predicted) | [color ]
white to beige | [biological source]
Albophoma yamanashiensis | [InChIKey]
SVYIMXYKHRBHSG-CDIJYFRTSA-N | [SMILES]
OC(C)(C)[C@H]1O[C@@]2([H])CC[C@]3(C)[C@]4(C)[C@@](CC5=C4NC6=C5C=CC=C6)([H])CCC3[C@]2(C)[C@H](O)C1 |
| Hazard Information | Back Directory | [Uses]
Acyl-coenzyme A:cholesterol acyltransferase (ACAT) isozymes are involved with cellular cholesterol esterification and regulate intestinal cholesterol absorption and hepatic lipoprotein secretion. Terpendole E is a related compound of Terpendole C (T116600), which is an inhibitor of ACAT1 and ACAT2 isozymes. | [Definition]
ChEBI: Terpendole E is an organic heterotricyclic compound and an organooxygen compound. | [Biochem/physiol Actions]
Terpendole E is a mitotic kinesin Eg5 (Kinesin-5) inhibitor isolated from Albophoma yamanashiensis that inhibits both motor and microtubule stimulated ATPase activities of human Eg5. Studies indicate that Terpendole E inhibits Eg5 mutants resistant to S-trityl-L-cysteine and other Eg5 inhibitors. Also, Terpendole E is an ACAT (Acyl-CoA:cholesterol acyltransferase) inhibitor. | [IC 50]
Eg5 |
|
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BOC Sciences
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Sigma-Aldrich
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Energy Chemical
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Merck KGaA
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