| Identification | Back Directory | [Name]
epolactaene | [CAS]
167782-17-4 | [Synonyms]
epolactaene
3,5,9-Undecatrienoic acid, 2-ethylidene-11-[(1R,5R)-4-hydroxy-4-methyl-2-oxo-6-oxa-3-azabicyclo[3.1.0]hex-1-yl]-4,10-dimethyl-11-oxo-, methyl ester, (2E,3E,5E,9E)- | [Molecular Formula]
C21H27NO6 | [MOL File]
167782-17-4.mol | [Molecular Weight]
389.44 |
| Hazard Information | Back Directory | [Uses]
Epolactaene is a potent Topoisomerase II and DNA Polymerase inhibitor with IC50 values of 10, 25, 94 μM for Topoisomerase II, DNA Polymerase α, DNA Polymerase β, respectively[1]. | [IC 50]
Topoisomerase II: 10 μM (IC50); DNA Polymerase α: 25 μM (IC50); DNA Polymerase β: 94 μM (IC50) | [References]
[1] Mizushina Y, et al. Epolactaene, a novel neuritogenic compound in human neuroblastoma cells, selectively inhibits the activities of mammalian DNA polymerases and human DNA topoisomerase II. Biochem Biophys Res Commun. 2000 Jul 5;273(2):784-8. DOI:10.1006/bbrc.2000.3007 |
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