| Identification | Back Directory | [Name]
Pregnane-11,20-dione, 2-(2,2-dimethyl-4-morpholinyl)-3-hydroxy-, (2β,3α,5α)- | [CAS]
167946-96-5 | [Synonyms]
Org21465
Org-21465
Org 21465
Pregnane-11,20-dione, 2-(2,2-dimethyl-4-morpholinyl)-3-hydroxy-, (2β,3α,5α)- | [Molecular Formula]
C27H43NO4 | [MDL Number]
MFCD00939712 | [MOL File]
167946-96-5.mol | [Molecular Weight]
445.64 |
| Hazard Information | Back Directory | [Description]
Org-21465 is a gamma-aminobutyric acid (GABA) receptor agonist potentially for the use of anesthesia. | [Uses]
Org 21465 is an agent that can relieve pain. Org 21465 causes no cardiovascular or respiratory depression. Org 21465 can inhibit GABAA receptor in vivo[1][2]. | [References]
[1] Vanlersberghe C, et, al. Etomidate and other non-barbiturates. Handb Exp Pharmacol. 2008:(182):267-82. DOI:10.1007/978-3-540-74806-9_13
[2] Visser SAG, et, al. Neuroactive steroids differ in potency but not in intrinsic efficacy at the GABA(A) receptor in vivo. J Pharmacol Exp Ther. 2002 Nov;303(2):616-26. DOI:10.1124/jpet.102.039610 |
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