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1681020-24-5

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1681020-24-5 Structure

1681020-24-5 Structure
IdentificationBack Directory
[Name]

DJ4
[CAS]

NoCAS
[Synonyms]

DJ4
[Molecular Formula]

C19H16N4OS
[MOL File]

1681020-24-5.mol
[Molecular Weight]

348.42
Chemical PropertiesBack Directory
[density ]

1.36±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
[form ]

Solid
[pka]

12.21±0.40(predicted)
[color ]

Off-white to light yellow
Hazard InformationBack Directory
[Uses]

DJ4 is a ATP-competitive inhibitor of ROCK1/2 (IC50 values:5 and 50 nM) and MRCKα/β (IC50 values:10 and 100 nM). DJ4 blocks stress fiber formation and induces cell apoptosis. DJ4 can be used for study of cancer[1].
[IC 50]

ROCK1: 5 nM (IC50); ROCK2: 50 nM (IC50)
[References]

[1] Kale VP, et al. A novel selective multikinase inhibitor of ROCK and MRCK effectively blocks cancer cell migration and invasion. Cancer Lett. 2014;354(2):299-310. DOI:10.1016/j.canlet.2014.08.032
Spectrum DetailBack Directory
[Spectrum Detail]

DJ4(1681020-24-5)1HNMR
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