| Identification | Back Directory | [Name]
AC-DEVD-CHO | [CAS]
169332-60-9 | [Synonyms]
MF 191
AC-DEVD-CHO
AC-DEVD-ALDEHYDE
AC-DEVD-CHO?, >98%
CASPASE-3 INHIBITOR
Ac-Asp-Glu-Val-Asp-H
ACETYL-DEVD-ALDEHYDE
CASPASE-3 INHIBITOR I
AC-DEVD-CHO USP/EP/BP
AC-ASP-GLU-VAL-ASP-CHO
CPP32/APOPAIN INHIBITOR
N-AC-ASP-GLU-VAL-ASP-CHO
N-ACETYL-ASP-GLU-VAL-ASP-AL
AC-ASP-GLU-VAL-ASP-ALDEHYDE
N-acetyl-Asp-Glu-Val-Asp-Ala
CASPASE-3 INHIBITOR (ALDEHYDE)
ACETYL-ASP-GLU-VAL-ASP-ALDEHYDE
AC-ASP-GLU-VAL-ASP-H (ALDEHYDE)
CASPASE 3 (APOPAIN) INHIBITOR 1
Acetyl-aspartyl-glutamyl-valyl-aspartal
Ac-DEVD-CHO，N-Acetyl-Asp-Glu-Val-Asp-al
N-ACETYL-ASP-GLU-VAL-ASP-CHO (ALDEHYDE)
AC-ASP-GLU-VAL-ASP-ALDEHYDE (PSEUDO ACID)
N-Acetyl-Asp-Glu-Val-Asp-al >=95%, powder
Ac-DEVD-CHO,N-Acetyl-Asp-Glu-Val-Asp-al, >98%
ACETYL-L-ASPARTYL-L-GLUTAMYL-L-VALYL-L-ASPART-1-AL
Caspase-3 Inhibitor I - CAS 169332-60-9 - Calbiochem
L-Valinamide, N-acetyl-L-α-aspartyl-L-α-glutamyl-N-[(1S)-2-carboxy-1-formylethyl]-
N-ACETYL-L-ALPHA-ASPARTYL-L-ALPHA-GLUTAMYL-N-(2-CARBOXY-1-FORMYLETHYL)-L VALINAMIDE
CASPASE-3 INHIBITOR I;N-AC-ASP-GLU-VAL-ASP-CHO;ACETYL-ASPARTYL-GLUTAMYL-VALYL-ASPARTAL
(4S,7S,10S,13S)-7-(2-carboxyethyl)-4-(carboxyMethyl)-13-forMyl-10-isopropyl-2,5,8,11-tetraoxo-3,6,9,12-tetraazapentadecan-15-oic acid | [Molecular Formula]
C20H30N4O11 | [MDL Number]
MFCD00671412 | [MOL File]
169332-60-9.mol | [Molecular Weight]
502.47 |
| Chemical Properties | Back Directory | [Boiling point ]
1021.1±65.0 °C(Predicted) | [density ]
1.374±0.06 g/cm3(Predicted) | [RTECS ]
EK7643000 | [storage temp. ]
-20°C | [solubility ]
H2O: 1 mg/mL
| [form ]
powder
| [pka]
4.19±0.10(Predicted) | [color ]
white
| [biological source]
synthetic | [Water Solubility ]
H2O: 1mg/mL | [Sensitive ]
Moisture Sensitive |
| Hazard Information | Back Directory | [Uses]
N-Acetyl-Asp-Glu-Val-Asp-al has been used as a caspase inhibitor in muscle samples, smooth muscle cells and Jurkat T-cells. | [Uses]
Reversible inhibitor of interleukin-1beta converting enzyme (ICE); also inhibits caspase-3 cleavage of poly(ADP-ribose) polymerase | [Definition]
ChEBI: A tetrapeptide consisting of two L-aspartic acid residues, an L-glutamyl residue and an L-valine residue with an acetyl group at the N-terminal and with the C-terminal carboxy group reduced to an aldehyde.
It is an inhibitor of caspase-3/7. | [General Description]
N-Acetyl-Asp-Glu-Val-Asp-al (Ac-DEVD-CHO) is a tetrapeptide with N-terminal acetylation and C-terminal aldehyde conjugation. | [Biochem/physiol Actions]
N-Acetyl-Asp-Glu-Val-Asp-al (Ac-DEVD-CHO) aids in the recovery of stunned myocardium by its caspase inhibition functionality. | [in vivo]
Compare with model group, in CI group, the concentrations of serum BUN are decreased significantly at all time points after operation and those of Cr are decreased significantly at 6 hours, then restored to those of the sham group at 12 hours and 24 hours; the concentrations of serum TNF-α, IL-6 are decreased and those of IL-10 are elevated significantly at all time points. [TNF-α (μg/L) 6 hours: 436.2±64.2 vs. 653.6±8.9, 12 hours: 233.4±85.4 vs. 579.7±137.1, 24 hours: 151.0±90.3 vs. 551.0±119.8, IL-6 (μg/L) 6 hours: 1033.2±345.8 vs. 1 595.3±159.4, 12 hours: 366.3±68.3 vs. 1 330.7±249.8, 24 hours: 241.2±208.4 vs. 815.3±572.7, IL-10 (μg/L) 6 hours: 33.6±10.4 vs. 26.6±4.5, 12 hours: 37.2±5.0 vs. 24.5±4.3, 24 hours: 38.3±5.5 vs. 18.2±1.6, all P<0.05]; the renal cell apoptosis rates are decreased significantly at all time points: apoptosis rates 6 hours: (13.9±3.2)% vs. (18.3±1.4)%, 12 hours: (10.5±3.6)% vs. (15.9±3.5)%, 24 hours: (8.4±1.8)% vs.(12.5±2.1)%[5]. | [IC 50]
Caspase 3: 0.23 nM (Ki); Caspase-8: 0.92 nM (Ki); Caspase-7: 1.6 nM (Ki); Caspase-10: 12 nM (Ki); Caspase-1: 18 nM (Ki); Caspase-6: 31 nM (Ki); Caspase-9: 60 nM (Ki); Caspase-4: 132 nM (Ki); Caspase-5: 205 nM (Ki); Caspase-2: 1710 nM (Ki) |
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| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
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