| Identification | Back Directory | [Name]
(N-[2-(2-CYCLOPROPYLMETHOXYPHENOXY)ETHYL]-5-CHLORO-ALPHA,ALPHA-DIMETHYL-1H-INDOLE-3-ETHANAMINE) HYDROCHLORIDE | [CAS]
169505-93-5 | [Synonyms]
RS-17053
RS17053HCl
RS 17053 HYDROCHLORIDE
RS 17053 hydrochloride (RS-17053)
RS 17053 hydrochloride (Synonyms: RS-17053)
(N-[2-(2-Cyclopropylmethoxyphenoxy)ethyl]-5-chloro-α,α-dimethyl-1H-indole-3-ethanamine)hydrochloride
(N-(2-(2-Cyclopropylmethoxyphenoxy)ethyl)-5-chloro-(a,a)-dimethyl-(1H)-indole-3-ethanamine)hydrochloride
(N-[2-(2-CYCLOPROPYLMETHOXYPHENOXY)ETHYL]-5-CHLORO-ALPHA,ALPHA-DIMETHYL-1H-INDOLE-3-ETHANAMINE) HYDROCHLORIDE | [Molecular Formula]
C24H30Cl2N2O2 | [MDL Number]
MFCD01074787 | [MOL File]
169505-93-5.mol | [Molecular Weight]
449.41 |
| Hazard Information | Back Directory | [Uses]
RS 17053 Hydrochloride is a selective a1A adrenoceptor antagonist. | [Biological Activity]
α 1A -adrenoceptor antagonist, with very high affinity for α 1A receptors (pK i and pA 2 estimates of 9.1-9.9) and a 30-100 fold selectivity over the α 1B and α 1D subtypes (pK i and pA 2 estimates 7.7-7.8). | [in vivo]
RS 17053 hydrochloride has a rapid onset of action, and a duration of action exceeding 60 min. RS 17053 hydrochloride pretreatment significantly alteres food intake [F(4, 132) 5 6.28, p , 0.0001]. 10 mg/kg RS-17053 significantly suppresses food intake[2]. | [storage]
Store at RT |
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