| Identification | Back Directory | [Name]
Geldanamycin, 17-demethoxy-17-[[3-(dimethylamino)propyl]amino]- | [CAS]
169521-68-0 | [Synonyms]
Geldanamycin, 17-demethoxy-17-[[3-(dimethylamino)propyl]amino]- | [Molecular Formula]
C33H50N4O8 | [MOL File]
169521-68-0.mol | [Molecular Weight]
630.78 |
| Hazard Information | Back Directory | [Uses]
17-DMAP-GA, a Geldanamycin (HY-15230) analogue, is an inhibitor of HSP90. 17-DMAP-GA causes cell cycle abnormalities[1][2]. | [References]
[1] Jurczyszyn A, et al. Geldanamycin and Its Derivatives Inhibit the Growth of Myeloma Cells and Reduce the Expression of the MET Receptor. J Cancer. 2014;5(6):480-490. Published 2014 May 31. DOI:10.7150/jca.8731
[2] Tian ZQ, et al. Synthesis and biological activities of novel 17-aminogeldanamycin derivatives. Bioorg Med Chem. 2004;12(20):5317-5329. DOI:10.1016/j.bmc.2004.07.053 |
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