| Identification | Back Directory | [Name]
BAY-545 | [CAS]
1699717-32-2 | [Synonyms]
BAY-545
BAY-545;BAY545;BAY 545;1699717-32-2
Thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione, 3-ethyl-6-[(4-hydroxy-1-piperidinyl)carbonyl]-5-methyl-1-(3,3,3-trifluoropropyl)- | [Molecular Formula]
C18H22F3N3O4S | [MDL Number]
MFCD32062683 | [MOL File]
1699717-32-2.mol | [Molecular Weight]
433.45 |
| Chemical Properties | Back Directory | [Boiling point ]
598.7±60.0 °C(Predicted) | [density ]
1.410±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:129.0(Max Conc. mg/mL);297.61(Max Conc. mM)
Ethanol:87.0(Max Conc. mg/mL);200.72(Max Conc. mM) | [form ]
A solid | [pka]
14.56±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
BAY-545 is a potent and selective A2B adenosine receptor antagonist, with an IC50 of 59 nM. BAY-545 also exhibits IC50s of 66, 400, 280 nM for human, mouse, rat A2B adenosine receptor in cells, respectively, and a Ki of 97 nM for human A2B adenosine receptor, with more selectivity over A1, A2A, and A3 adenosine receptor[1]. | [storage]
Store at -20°C | [References]
[1] H?rter M, et al. Novel non-xanthine antagonist of the A2B adenosine receptor: From HTS hit to lead structure. Eur J Med Chem. 2019 Feb 1;163:763-778. DOI:10.1016/j.ejmech.2018.11.045 |
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| Company Name: |
BOC Sciences
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| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
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