| Identification | Back Directory | [Name]
acyline | [CAS]
170157-13-8 | [Synonyms]
acyline
ZWNUQDJANZGVFO-YHSALVGYSA-N
D-Alaninamide, N-acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-4-(acetylamino)-L-phenylalanyl-4-(acetylamino)-D-phenylalanyl-L-leucyl-N6-(1-methylethyl)-L-lysyl-L-prolyl- | [Molecular Formula]
C80H102ClN15O14 | [MDL Number]
MFCD19382609 | [MOL File]
170157-13-8.mol | [Molecular Weight]
1533.21 |
| Hazard Information | Back Directory | [Uses]
Acyline, a GnRH peptide analogue, is a GnRH antagonist that inhibits gonadotropin and testosterone (T) levels[1]. | [in vivo]
Acyline (50 μg, s.c., twice daily, 5 days) can result in disruption of vaginal oestrus and reduce uterine weights in female Kiss1?/?and?Gpr54?/??mice, as well as a decrease in LH concentrations of female?Kiss1?/? mice[1].
Acyline (50 μg, s.c., once) can?reduce FSH concentrations?from?pre-acyline 1.51 ng/mL to post-acyline 1.27 ng/mL in male Kiss1?/? mice and from?pre-acyline 2.87 ng/mL to post-acyline 1.95 ng/mL in male Gpr54?/??mice[1].
| Animal Model: | Female Kiss1?/?and?Gpr54?/??mice[1] | | Dosage: | 50 μg (1 mg/mL in PBS) | | Administration: | Subcutaneous injection; twice daily; 5 days | | Result: | 12 Kiss1?/??mice left oestrus within 4 days of 13 mice received acyline while only 2 of 17 mice received vehicle left oestrus.?Also, 7 of 8?Gpr54?/??mice received acyline left oestrus compared to 1 of 7 received vehicle.
Reduced uterine weights of?Kiss1?/?and?Gpr54?/? mice in treated group compared to the vehicle group, and reduced serum LH concentrations in Kiss1?/? mice. |
| [References]
[1] Y M Chan, et al. Kisspeptin/Gpr54-independent gonadotrophin-releasing hormone activity in Kiss1 and Gpr54 mutant mice. J Neuroendocrinol. 2009 Dec;21(12):1015-23. DOI:10.1111/j.1365-2826.2009.01926.x |
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