| Identification | Back Directory | [Name]
KW-8232 free base | [CAS]
170365-25-0 | [Synonyms]
KW-8232 free base
Methanone, [3-[bis(4-hydroxyphenyl)methyl]-1-[2-(dimethylamino)ethyl]-1H-indol-2-yl][4-(2-chlorophenyl)-1-piperazinyl]- | [Molecular Formula]
C36H37ClN4O3 | [MDL Number]
MFCD30533346 | [MOL File]
170365-25-0.mol | [Molecular Weight]
609.16 |
| Chemical Properties | Back Directory | [Boiling point ]
805.5±65.0 °C(Predicted) | [density ]
1.26±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
9.95±0.10(Predicted) | [color ]
Off-white to pink |
| Hazard Information | Back Directory | [Uses]
KW-8232 free base, an orally active anti-osteoporotic agent, and can reduces the biosynthesis of PGE2[1]. | [in vivo]
KW-8232 (3, 10, 30 mg/kg, p.o.) potently increases the femoral bone mineral density (BMD) of immobilized legs of rats, and affects immobilization-induced abnormal bone turnovrer. KW-8232 markedly decreases urinary calcium excreation in the neurectomized rats only at 30 mg/kg, and highly reduces urinary pyridinoline and deoxypyridionline excretion which are markers of bone resorption in neurectomized rats. KW-8232 inhibits bone loss may be attributed to the lower prostaglandins (PGs)-stimulated bone resorption via regulation of PGE2 production[1]. | Animal Model: | male Sprague-Dawley rats (5-week-old)[1]. | | Dosage: | 1, 3, 10, and 30 mg/kg. | | Administration: | Orally once daily beginning 1 day prior to neurectomy for 28 days. | | Result: | Decreased urinary calcium excreation in the neurectomized rats only at 30 mg/kg. |
| [IC 50]
EP | [storage]
Store at -20°C | [References]
[1] Uchii M, et al. Effect of KW-8232, a novel anti-osteoporotic agent, on bone loss in sciatic neurectomized rats. Jpn J Pharmacol. 1998 Oct;78(2):241-3. DOI:10.1254/jjp.78.241
[2] Shiwei Wang, et al. A Transferable Deep Learning Approach to Fast Screen Potent Antiviral Drugs against SARS-CoV-2. bioRxiv. 2020. |
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