| Identification | Back Directory | [Name]
(4aS,5aR)-N-[1-[(R)-[(2R)-1,1-dioxothian-2-yl]-phenylmethyl]pyrazol-4-yl]-5,5-difluoro-5a-methyl-1,4,4a,6-tetrahydrocyclopropa[f]indazole-3-carboxamide | [CAS]
1705602-02-3 | [Synonyms]
GNE-4997
(4aS,5aR)-N-[1-[(R)-[(2R)-1,1-dioxothian-2-yl]-phenylmethyl]pyrazol-4-yl]-5,5-difluoro-5a-methyl-1,4,4a,6-tetrahydrocyclopropa[f]indazole-3-carboxamide | [Molecular Formula]
C25H27F2N5O3S | [MDL Number]
MFCD31692422 | [MOL File]
1705602-02-3.mol | [Molecular Weight]
515.58 |
| Chemical Properties | Back Directory | [Boiling point ]
727.0±60.0 °C(Predicted) | [density ]
1.58±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [pka]
11.35±0.60(Predicted) |
| Hazard Information | Back Directory | [Description]
GNE-4997 is a potent and selective ITK inhibitor (Ki = 0.09 nM). | [Uses]
GNE-4997 is a potent and selective interleukin-2-inducible T-cell kinase (ITK) inhibitor with a Ki of 0.09 nM, and the correlation between the basicity of solubilizing elements in GNE-4997 and off-target antiproliferative effects reduces cytotoxicity[1]. | [storage]
Store at -20°C | [References]
[1] Burch JD, et al. Tetrahydroindazoles as Interleukin-2 Inducible T-Cell Kinase Inhibitors. Part II. Second-Generation Analogues with Enhanced Potency, Selectivity, and Pharmacodynamic Modulation in Vivo. J Med Chem. 2015 May 14;58(9):3806-16. DOI:10.1021/jm501998m |
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