| Identification | Back Directory | [Name]
4-[5-(4-FLUOROPHENYL)-3-(TRIFLUOROMETHYL)PYRAZOL-1-YL]BENZENE-1-SULFONAMIDE | [CAS]
170569-88-7 | [Synonyms]
Trocoxil
Mavacoxib
PHA 739521
Mavacoxibd
4-[5-(4-Fluoro-phenyl)-3-trifluoromethyl-pyrazol-1-yl]-benzenesulfonamide
4-[5-(4-FLUOROPHENYL)-3-(TRIFLUOROMETHYL)PYRAZOL-1-YL]BENZENE-1-SULFONAMIDE
4-[5-(4-Fluorophenyl)-3-trifluoroMethyl-1H-pyrazol-1-yl] benzenesulfonaMide
BenzenesulfonaMide, 4-[5-(4-fluorophenyl)-3-(trifluoroMethyl)-1H-pyrazol-1-yl]-
4-[5-(4-FLUOROPHENYL)-3-(TRIFLUOROMETHYL)PYRAZOL-1-YL]BENZENE-1-SULFONAMIDE USP/EP/BP | [Molecular Formula]
C16H11F4N3O2S | [MOL File]
170569-88-7.mol | [Molecular Weight]
385.34 |
| Questions And Answer | Back Directory | [Synthesis]
To a 250 ml three-necked flask, ethyl trifluoroacetate (13.60 g, 0.0958 mol), ethanol (20 ml), and a methanol solution of 28.4% sodium methoxide (16.50 g, 0.0868 mol) were added sequentially. Then, 4-fluoroacetophenone (10.00 g, 0.0725 mol) was added dropwise while stirring. After the addition was complete, the reaction solution was heated to 10–15 °C and reacted for 2.5 hours. Then, acetic acid (6.54 g, 0.109 mol) was added dropwise. After the addition was complete, 4-aminosulfonylphenylhydrazine hydrochloride was slowly added. The reaction solution was then reacted at 15 °C for 2 hours. The reaction solution was cooled to 5 °C and then the pH was adjusted to 7 with 50% sodium hydroxide. Ethanol (37 ml) and water (31 ml) were added, and the temperature was raised to 30 °C. Water (32 ml) was slowly added to the reaction solution. The reaction solution was cooled to 5°C, filtered, and the filter cake was washed twice with 50% ethanol-water solution (v/v, 50 g). The filter cake was vacuum dried to give 20.109 g of the final product, with a yield of 72.0%. |
| Chemical Properties | Back Directory | [Boiling point ]
519.8±60.0 °C(Predicted) | [density ]
1.51±0.1 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,2-8°C | [pka]
9.67±0.10(Predicted) |
| Hazard Information | Back Directory | [Uses]
4-[5-(4-FLUOROPHENYL)-3-(TRIFLUOROMETHYL)PYRAZOL-1-YL]BENZENE-1-SULFONAMIDE is a long-acting COX-2 Inhibitor and is developed as a veterinary drug used to treat pain and inflammation with degenerative joint disease for dogs.
| [Definition]
4-[5-(4-FLUOROPHENYL)-3-(TRIFLUOROMETHYL)PYRAZOL-1-YL]BENZENE-1-SULFONAMIDE is a member of the class of pyrazoles that is 1H-pyrazole which is substituted at positions 1, 3 and 5 by 4-sulfamoylphenyl, trifluoromethyl and 4-fluorophenyl groups, respectively. A selective cyclooxygenase 2 inhibitor, it is used in vete inary medicine to treat pain and inflammation in dogs with degenerative joint disease.
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| Company Name: |
J & K SCIENTIFIC LTD.
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18210857532 18210857532 |
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https://www.jkchemical.com |
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sgtlifesciences pvt ltd
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+91-8790379245 |
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https://www.chemicalbook.com/ShowSupplierProductsList1846349/0.htm |
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AFINE CHEMICALS LIMITED
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+86-571-85134551 +86-18958018566 |
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www.afinechem.com/index.html |
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