| Identification | Back Directory | [Name]
Zapalog | [CAS]
1708091-24-0 | [Synonyms]
Zapalog
2-Piperidinecarboxylic acid, 1-(3,3-dimethyl-1,2-dioxopentyl)-, (1R)-1-[3-[[4-[4-[1-[2-[4-[(2,4-diamino-5-pyrimidinyl)methyl]-2,6-dimethoxyphenoxy]ethoxy]ethyl]-2-methoxy-5-nitrophenoxy]-1-oxobutyl]amino]phenyl]-3-(3,4-dimethoxyphenyl)propyl ester, (2S)- | [Molecular Formula]
C58H73N7O15 | [MDL Number]
MFCD32201094 | [MOL File]
1708091-24-0.mol | [Molecular Weight]
1108.24 |
| Chemical Properties | Back Directory | [density ]
1.260±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 100 mg/mL (90.23 mM; Need ultrasonic) | [form ]
Solid | [pka]
14.46±0.70(Predicted) | [color ]
White to yellow |
| Hazard Information | Back Directory | [Uses]
Zapalog is a photocleavable small-molecule heterodimerizer that can be used to repeatedly initiate, and instantaneously terminate, a physical interaction between two target proteins. Zapalog dimerizes any two proteins tagged with the FKBP and DHFR domains until exposure to light causes its photolysis[1]. | [storage]
Store at -20°C | [References]
[1] Gutnick A, et al. The light-sensitive dimerizer zapalog reveals distinct modes of immobilization for axonal mitochondria. Nat Cell Biol. 2019 Jun;21(6):768-777. DOI:10.1038/s41556-019-0317-2 |
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