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1708103-69-8

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1708103-69-8 Structure

1708103-69-8 Structure
IdentificationBack Directory
[Name]

2-Butenediamide, N1-[3-(aminocarbonyl)phenyl]-N4-methyl-, (2Z)-
[CAS]

1708103-69-8
[Synonyms]

ARTD10/PARP10-IN-2
2-Butenediamide, N1-[3-(aminocarbonyl)phenyl]-N4-methyl-, (2Z)-
[Molecular Formula]

C12H13N3O3
[MOL File]

1708103-69-8.mol
[Molecular Weight]

247.25
Chemical PropertiesBack Directory
[Boiling point ]

587.1±50.0 °C(Predicted)
[density ]

1.299±0.06 g/cm3(Predicted)
[pka]

11.80±0.70(Predicted)
Hazard InformationBack Directory
[Uses]

ARTD10/PARP10-IN-2 (compound 19) is a potent and non-selective PARP inhibitor, targeting to mono-ADP-ribosyltransferases ARTD10/PARP10 and poly(ADP-ribose) polymerase-1 ARTD1/PARP1 with IC50s of 2.0 μM, and 9.7 μM, respectively[1].
[IC 50]

ARTD1/PARP1: 9.7 μM (IC50); ARTD10/PARP10: 2.0 μM (IC50); ARTD8/PARP14: >20 μM (IC50); ARTD7/PARP15: >20 μM (IC50)
[References]

[1] Ekblad T, et al. Towards small molecule inhibitors of mono-ADP-ribosyltransferases. Eur J Med Chem. 2015 May 5;95:546-51. DOI:10.1016/j.ejmech.2015.03.067
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