| Identification | Back Directory | [Name]
2-Butenoic acid, 4-[[3-(aminocarbonyl)phenyl]amino]-4-oxo-, methyl ester, (2Z)- | [CAS]
1708103-76-7 | [Synonyms]
PARP10-IN-1
ARTD10/PARP10-IN-1
2-Butenoic acid, 4-[[3-(aminocarbonyl)phenyl]amino]-4-oxo-, methyl ester, (2Z)- | [Molecular Formula]
C12H12N2O4 | [MOL File]
1708103-76-7.mol | [Molecular Weight]
248.23 |
| Hazard Information | Back Directory | [Uses]
ARTD10/PARP10-IN-1 (compound 23) is a potent and non-selective PARP inhibitor, targeting to mono-ADP-ribosyltransferases ARTD7/PARP15, ARTD8/PARP14, ARTD10/PARP10 and poly(ADP-ribose) polymerase-1 (ARTD1/PARP1) with IC50s of 1.7 μM, 1.6 μM, 0.8 μM, and 4.4 μM, respectively[1]. | [IC 50]
ARTD1/PARP1: 4.4 μM (IC50); ARTD10/PARP10: 0.8 μM (IC50); ARTD8/PARP14: 1.6 μM (IC50); ARTD7/PARP15: 1.7 μM (IC50) | [References]
[1] Ekblad T, et al. Towards small molecule inhibitors of mono-ADP-ribosyltransferases. Eur J Med Chem. 2015 May 5;95:546-51. DOI:10.1016/j.ejmech.2015.03.067 |
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