| Identification | Back Directory | [Name]
acutumine | [CAS]
17088-50-5 | [Synonyms]
acutumine
(1R,3'aS,5S,7'aS,9'S)-9'-Chloro-2',3'-dihydro-5-hydroxy-4,6',7'-trimethoxy-1'-methylspiro[3-cyclopentene-1,10'-[3a,7a]propano[1H]indole]-2,5'(4'H)-dione
Spiro[3-cyclopentene-1,10'-[3a,7a]propano[1H]indole]-2,5'(4'H)-dione, 9'-chloro-2',3'-dihydro-5-hydroxy-4,6',7'-trimethoxy-1'-methyl-, (1R,3'aS,5S,7'aS,9'S)- | [Molecular Formula]
C19H24ClNO6 | [MOL File]
17088-50-5.mol | [Molecular Weight]
397.85 |
| Hazard Information | Back Directory | [Uses]
(?)-Acutumine is a tetracyclic chloroalkaloid that exhibits selective cytotoxicity to cultured human T cells and memory-enhancing properties in the Wistar rat model[1]. | [Definition]
ChEBI: Acutumine is an alkaloid. | [References]
[1] Kim CY, et al. The chloroalkaloid (-)-acutumine is biosynthesized via a Fe(II)- and 2-oxoglutarate-dependent halogenase in Menispermaceae plants. Nat Commun. 2020 Apr 20;11(1):1867. DOI:10.1038/s41467-020-15777-w |
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