| Identification | Back Directory | [Name]
1,4-Pentadien-3-one, 1,5-bis(2,3-dimethoxyphenyl)-, (1E,4E)- | [CAS]
170950-29-5 | [Synonyms]
Go Y015
Go-Y015
TrxR1INB19
TrxR1-IN-B19
TrxR1 IN B19
1,4-Pentadien-3-one, 1,5-bis(2,3-dimethoxyphenyl)-, (1E,4E)- | [Molecular Formula]
C21H22O5 | [MOL File]
170950-29-5.mol | [Molecular Weight]
354.4 |
| Chemical Properties | Back Directory | [Melting point ]
134-136 °C(Solv: ethyl ether (60-29-7)) | [Boiling point ]
510.7±50.0 °C(Predicted) | [density ]
1.147±0.06 g/cm3(Predicted) |
| Hazard Information | Back Directory | [Description]
TrxR1-IN-B19 is a TrxR1 inhibitor. It selectively kills gastric cancer cells by a small molecule via targeting TrxR1 and ROS-mediated ER stress activation. | [Uses]
TrxR1-IN-B19 (GO-Y015) (Compound B19) is a Curcumin (HY-N0005) derivative and colvalent TrxR1 inhibitor. TrxR1-IN-B19 inhibits TrxR1 enzyme activity to elevate oxidative stress, and then induce ROS-mediated ER Stress and mitochondrial dysfunction, subsequently resulting in cell cycle arrest and apoptosis[1]. | [References]
[1] Chen W,et al. Selective killing of gastric cancer cells by a small molecule via targeting TrxR1 and ROS-mediated ER stress activation. Oncotarget. 2016 Mar 29;7(13):16593-609. DOI:10.18632/oncotarget.7565 |
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