| Identification | Back Directory | [Name]
AGN192836 | [CAS]
171102-29-7 | [Synonyms]
AGN192836
1H-Imidazol-2-amine, N-(2,3-dihydro-5-methyl-1,4-benzodioxin-6-yl)- | [Molecular Formula]
C12H13N3O2 | [MDL Number]
MFCD00941734 | [MOL File]
171102-29-7.mol | [Molecular Weight]
231.25 |
| Chemical Properties | Back Directory | [Boiling point ]
411.2±55.0 °C(Predicted) | [density ]
1.342±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
14.29±0.10(Predicted) | [color ]
Off-white to pale purple |
| Hazard Information | Back Directory | [Uses]
AGN 192836 is a potent and selective α2 adrenergic agonist with EC50s of 8.7, 41 and 6.6 nM for α2A, α2B and α2C receptor, respectively. | [in vivo]
AGN 192836 is equally efficacious when compared to brimonidine for the reduction of intraocular pressure upon topical administration to the rabbit and more efficacious than brimonidine for the reduction of blood pressure upon intravenous administration to monkey[1]. | [IC 50]
α adrenergic receptor | [References]
[1] Stephen M, et al. Synthesis and Evaluation of 2-(Arylamino)imidazoles as α2-Adrenergic Agonists. J. Med. Chem., 1997, 40 (1), pp 18–23 |
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