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171486-59-2

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171486-59-2 Structure

171486-59-2 Structure
IdentificationBack Directory
[Name]

N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-propargyladenosine-3'-O-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite
[CAS]

171486-59-2
[Synonyms]

2'-O-Propargyl A(Bz)-3'-phosphoramidite
N6-Bz-5’-O-DMTr-2’-O-propargyladenosine-3’-CED-phosphora midite
N6-Benzoyl-5'-O-DMT-2'-O-propynyladenosine 3'-CE phosphoramidite
N6-Bz-5’-O-DMTr-2’-O-propargyladenosine-3’-CED-phosphora midite, 2’-O-Propargyl A(Bz)-3’-phosphoramidite
N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-propargyladenosine-3'-O-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite
N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-propargyladeno sine-3'-O-[(2-cyano-ethyl)-(N,N-diisopropyl)]phosphorami dite
Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-2-propyn-1-yl-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
[Molecular Formula]

C50H54N7O8P
[MOL File]

171486-59-2.mol
[Molecular Weight]

912
Chemical PropertiesBack Directory
[pka]

7.87±0.43(Predicted)
Hazard InformationBack Directory
[Uses]

2'-O-Propargyl A(Bz)-3'-phosphoramidite is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277)[1].
[References]

[1] Man S, et al. Potential and promising anticancer drugs from adenosine and its analogs. Drug Discov Today. 2021 Jun;26(6):1490-1500. DOI:10.1016/j.drudis.2021.02.020
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