| Identification | Back Directory | [Name]
L-Lysine, L-α-aspartyl-L-seryl-L-alanyl-L-phenylalanyl-L-α-aspartyl-L-valyl-L-leucyl-L-seryl-L-phenylalanyl-L-threonyl-L-alanyl-L-α-glutamyl-L-α-glutamyl-L-lysyl-L-alanylglycyl-L-valyl-L-tyrosyl- | [CAS]
171675-09-5 | [Synonyms]
Myhc-α(334–352)
L-Lysine, L-α-aspartyl-L-seryl-L-alanyl-L-phenylalanyl-L-α-aspartyl-L-valyl-L-leucyl-L-seryl-L-phenylalanyl-L-threonyl-L-alanyl-L-α-glutamyl-L-α-glutamyl-L-lysyl-L-alanylglycyl-L-valyl-L-tyrosyl- | [Molecular Formula]
C94H141N21O32 | [MOL File]
171675-09-5.mol | [Molecular Weight]
2077.25 |
| Chemical Properties | Back Directory | [Boiling point ]
2259.2±65.0 °C(Predicted) | [density ]
1.335±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
3.27±0.10(Predicted) | [color ]
White to off-white | [Sequence]
Asp-Ser-Ala-Phe-Asp-Val-Leu-Ser-Phe-Thr-Ala-Glu-Glu-Lys-Ala-Gly-Val-Tyr-Lys |
| Hazard Information | Back Directory | [Uses]
Myhc-α(334–352) is a sequence fragment of amino acid residues 334 to 352 of cardiac myosin heavy chain α. Myhc-α(334–352) is an immunodominant epitope that can induce autoimmune reactions in A/J mice, leading to the occurrence of myocarditis. Myhc-α(334–352) can be used to study the autoimmune pathways of myocarditis and dilated cardiomyopathy[1]. | [References]
[1] Massilamany C, et al. Identification of novel mimicry epitopes for cardiac myosin heavy chain-α that induce autoimmune myocarditis in A/J mice[J]. Cellular immunology, 2011, 271(2): 438-449. DOI:10.1016/j.cellimm.2011.08.013 |
|
|