| Identification | Back Directory | [Name]
(1S–4R)-4-(2-amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol hydrochloride | [CAS]
172015-79-1 | [Synonyms]
Abacavir Related CoMpound C
( Abacavir USP Related Compound C)
Abacavir Impurity 8( Abacavir USP Related Compound C)
(1S,4R)-4-(2-AMino-6-chloro-9H-purin-yl)-2-cyclopentene-1-Methanol,HCl
[(1R,4S)-4-(2-Amino-6-chloro-9H-purin-9-yl)cyclopent-2-en-1-yl]methanol
(1S,4R)-4-(2-Amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol HCl
(1S,4R)-4-(2-amino-6-chloropurin-9-yl)cyclopent-2-en-1-yl]methanol,hydrochloride
[(1S,4R)-4-(2-Amino-6-chloro-9H-purin-9-yl)cyclopent-2-enyl]methanol hydrochloride
(1S–4R)-4-(2-amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol hydrochloride
(1S,4R)-4-(2-amino-6-chloro-9H-purin-9-yl) -2-Cyclopentene-1- methano Hydrochloride
((1S,4R)-4-(2-Amino-6-chloro-9H-purin-9-yl)cyclopent-2-en-1-yl)methanol hydrochloride
(1S-cis)-4-(2-AMino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-Methanol Monohydrochloride
SIM 2142 (1S,4R)-4-(2-amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanolhydrochloride 172015-79-1 100gm
Abacavir Related Compound C (20 mg) ([(1S,4R)-4-(2-amino-6-chloro-9H-purin-9-yl)cyclopent-2-enyl]methanol hydrochloride) | [Molecular Formula]
C11H12ClN5O.ClH | [MDL Number]
MFCD13195618 | [MOL File]
172015-79-1.mol | [Molecular Weight]
302.164 |
| Chemical Properties | Back Directory | [Melting point ]
165-170?C | [storage temp. ]
Inert atmosphere,2-8°C | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
neat | [color ]
Off-White to Beige to Brown | [Major Application]
pharmaceutical (small molecule) | [InChI]
1S/C11H12ClN5O.ClH/c12-9-8-10(16-11(13)15-9)17(5-14-8)7-2-1-6(3-7)4-18;/h1-2,5-7,18H,3-4H2,(H2,13,15,16);1H/t6-,7+;/m1./s1 | [InChIKey]
VZJFPECAPXUELG-HHQFNNIRSA-N | [SMILES]
Clc1nc(nc2[n](cnc21)[C@@H]3C[C@@H](C=C3)CO)N.Cl |
| Hazard Information | Back Directory | [Chemical Properties]
Off-White to Tan Solid | [Uses]
Abacavir intermediate. | [Synthesis]
The general procedure for the synthesis of ((1S,4R)-4-(2-amino-6-chloro-9H-purin-9-yl)cyclopent-2-en-1-yl)methanol hydrochloride from abacavir intermediate A4 was as follows: to the reactor was added N-[2-amino-4-chloro-6-[[(1R,4S)-4-(hydroxymethyl)-2-cyclopenten-1-yl]amino]-5-pyrimidinyl] Formamide (0.1762 mol) and trichloromethylsilicate (7 vol). The reaction mixture was cooled to 0-5 °C and hydrochloric acid (0.7 vol) was added slowly at 0-10 °C. After addition, the reaction was held at 0-5 °C for 60 min. Subsequently, the reaction mixture was brought to room temperature and stirring was continued for 16-18 hours. Upon completion of the reaction, the solid product was collected by filtration and purified by recrystallization in methanol. (Yield: 76%, HPLC purity: 98.69%). | [References]
[1] Nucleosides, Nucleotides and Nucleic Acids, 2000, vol. 19, # 1-2, p. 297 - 327
[2] Patent: US2017/233329, 2017, A1. Location in patent: Paragraph 0054; 0055
[3] Patent: CN107641122, 2018, A. Location in patent: Paragraph 0016; 0049; 0055-0056; 0059-0073; 0076 |
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