| Identification | Back Directory | [Name]
SHK | [CAS]
172450-46-3 | [Synonyms]
SHK
SHNA
SHPK
CARKL
Sedoheptulokinase
STICHODACTYLA TOXIN
Carbohydrate kinase-like protein
STICHODACTYLA HELIANTHUS NEUROTOXIN
Recombinant Human SHPK Protein, His Tag
STICHODACTYLA HELIANTHUS NEUROTOXIN (SHK)
STICHODACTYLA HELIANTHUS NEUROTOXIN (SHNA)
Anti-CARKL, N-Terminal antibody produced in rabbit
Toxin ShK(Stoichactis helianthus potassium-channel)
ARG-SER-CYS-ILE-ASP-THR-ILE-PRO-LYS-SER-ARG-CYS-THR-ALA-PHE-GLN-CYS-LYS-HIS-SER-MET-LYS-TYR-ARG-LEU-SER-PHE-CYS-ARG-LYS-THR-CYS-GLY-THR-CYS
H-ARG-SER-CYS-ILE-ASP-THR-ILE-PRO-LYS-SER-ARG-CYS-THR-ALA-PHE-GLN-CYS-LYS-HIS-SER-MET-LYS-TYR-ARG-LEU-SER-PHE-CYS-ARG-LYS-THR-CYS-GLY-THR-CYS-OH
H-ALA-ALA-CYS-LYS-CYS-ASP-ASP-GLU-GLY-PRO-ASP-ILE-ARG-THR-ALA-PRO-LEU-THR-GLY-THR-VAL-ASP-LEU-GLY-SER-CYS-ASN-ALA-GLY-TRP-GLU-LYS-CYS-ALA-SER-TYR-TYR-THR-ILE-ILE-ALA-ASP-CYS-CYS-ARG-LYS-LYS-LYS-OH | [Molecular Formula]
C169H274N54O48S7 | [MDL Number]
MFCD00212724 | [MOL File]
172450-46-3.mol | [Molecular Weight]
4054.77 |
| Chemical Properties | Back Directory | [storage temp. ]
-15°C
| [Sequence]
Arg-Ser-Cys-Ile-Asp-Thr-Ile-Pro-Lys-Ser-Arg-Cys-Thr-Ala-Phe-Gln-Cys-Lys-His-Ser-Met-Lys-Tyr-Arg-Leu-Ser-Phe-Cys-Arg-Lys-Thr-Cys-Gly-Thr-Cys (Disulfide bridge: Cys3-Cys35; Cys12-Cys28; Cys17-Cys32) |
| Hazard Information | Back Directory | [Uses]
ShK toxin blocks voltage-dependent potassium channel (Kv1.3 channel). ShK toxin can be isolated from the whole body extract of the Caribbean sea anemone (Stichodactylu helianthus). ShK toxin competes with dendrotoxin I and α-dendrotoxin for binding to synaptosomal membranes of rat brain, facilitates acetylcholine release. ShK toxin suppresses K+ currents in cultured rat dorsal root ganglion neurons. ShK toxin also inhibits T lymphocyte proliferation[1][2]. | [References]
[1] Casta?eda O, et al. Characterization of a potassium channel toxin from the Caribbean Sea anemone Stichodactyla helianthus. Toxicon. 1995 May;33(5):603-13. DOI:10.1016/0041-0101(95)00013-c
[2] Beeton C, et al. The D-diastereomer of ShK toxin selectively blocks voltage-gated K+ channels and inhibits T lymphocyte proliferation. J Biol Chem. 2008 Jan 11;283(2):988-97. DOI:10.1074/jbc.M706008200 |
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