| Identification | Back Directory | [Name]
N3-PEG3-CH2COOtBu | [CAS]
172531-36-1 | [Synonyms]
Azido-PEG3-C-Boc
N3-PEG3-CH2COOtBu
Azido-PEG3-CH2CO2-t-Bu
azidotriethyleneglycol-Boc
Azido-PEG3-CH2CO2-t-butyl ester
tert-Butyl 11-azido-3,6,9-trioxaundecanoate | [Molecular Formula]
C12H23N3O5 | [MDL Number]
MFCD20134124 | [MOL File]
172531-36-1.mol | [Molecular Weight]
289.328 |
| Hazard Information | Back Directory | [Description]
Azido-PEG3-CH2CO2-t-Bu is a N3 (azide) containing t-butyl ester. The hydrophilic PEG spacer increases solubility in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The t-butyl protected carboxyl group can be deprotected under acidic conditions. | [Uses]
Azido-PEG3-C-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG3-C-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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