| Identification | Back Directory | [Name]
LY 266097 hydrochloride | [CAS]
172895-39-5 | [Synonyms]
LY266097
LY 266097
LY 266097 hydrochloride
LY266097 >=98% (HPLC), powder
LY-266097 hydrochloride,LY266097 hydrochloride
1-[(2-Chloro-3,4-dimethoxyphenyl)methyl]-2,3,4,9-tetrahydro-6-methyl-1H-pyrido[3,4-b]indole hydrochloride | [Molecular Formula]
C21H24Cl2N2O2 | [MDL Number]
MFCD00949080 | [MOL File]
172895-39-5.mol | [Molecular Weight]
407.34 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
DMSO: ≥20mg/mL | [form ]
powder | [color ]
white to tan | [InChI]
1S/C21H23ClN2O2.ClH/c1-12-4-6-16-15(10-12)14-8-9-23-17(20(14)24-16)11-13-5-7-18(25-2)21(26-3)19(13)22;/h4-7,10,17,23-24H,8-9,11H2,1-3H3;1H | [InChIKey]
KPXKZZURYAXZQE-UHFFFAOYSA-N | [SMILES]
Cl.COc1ccc(CC2NCCc3c2[nH]c4ccc(C)cc34)c(Cl)c1OC |
| Hazard Information | Back Directory | [Uses]
LY 266097 Hydrochloride is a potent and selective serotonin 2B (5HT2B) contractile receptor. | [Biological Activity]
LY266097 is a selective 5HT-2B antagonist with a pKI of 9.7 for the human cloned 5-HT2B receptor and a 100-fold greater selectivity for 5-HT2B than the human 5-HT2C and 5-HT2A. | [in vivo]
LY266097 (0.6 mg/kg for 2-day administration) rescues Escitalopram-induced decrease in dopamine (DA) [1].
The administration of LY266097 alone or its addition on the last 3 days of a 14-day Escitalopram regimen increases pyramidal neuron firing and burst activity[1]. | Animal Model: | Male Sprague-Dawley rats weighing 250-350?g[1] | | Dosage: | 0.6?mg/kg | | Administration: | Administered i.p. alone or concomitantly with Escitalopram (2?mg/kg) for 2 days | | Result: | Short-term administration (0.6?mg/kg/day for 2 days; i.p.) alone had no effect on these parameters, its co-administration counteracted the inhibitory effect of escitalopram on the firing activity of DA neurons, resulting in a recovery to control level. |
| [IC 50]
5-HT2B Receptor: 9.8 (pKi); 5-HT2A Receptor: 7.7 (pKi); 5-HT2C Receptor: 7.6 (pKi) | [storage]
Store at +4°C |
|
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|