| Identification | Back Directory | [Name]
PB28dihydrochloride | [CAS]
172906-90-0 | [Synonyms]
PB-28
PB28 dihydrochloride >=98% (HPLC), solid
Piperazine,1-cyclohexyl-4-[3-(1,2,3,4-tetrahydro-5-methoxy-1-naphthalenyl)propyl]-
1-Cyclohexyl-4-[3-(1,2,3,4-tetrahydro-5-methoxy-1-naphthalenyl)propyl]piperazinedihydrochloride | [Molecular Formula]
C24H38N2O | [MDL Number]
MFCD06798349 | [MOL File]
172906-90-0.mol | [Molecular Weight]
370.57 |
| Chemical Properties | Back Directory | [Boiling point ]
501.4±50.0 °C(Predicted) | [density ]
1.032±0.06 g/cm3(Predicted) | [storage temp. ]
Desiccate at +4°C | [solubility ]
H2O: ~10mg/mL at 60°C | [form ]
solid | [pka]
8.32±0.70(Predicted) | [color ]
white | [Water Solubility ]
H2O: ~10mg/mL at60°C | [InChI]
1S/C24H38N2O.2ClH/c1-27-24-14-6-12-22-20(8-5-13-23(22)24)9-7-15-25-16-18-26(19-17-25)21-10-3-2-4-11-21;;/h6,12,14,20-21H,2-5,7-11,13,15-19H2,1H3;2*1H | [InChIKey]
DSRBJOQIBXACIV-UHFFFAOYSA-N | [SMILES]
Cl[H].Cl[H].COc1cccc2C(CCCN3CCN(CC3)C4CCCCC4)CCCc12 |
| Hazard Information | Back Directory | [Uses]
PB 28 is a selective σ2 receptor agonist. It is also an antitumor and cytotoxic agent. | [Definition]
ChEBI: PB28 is a member of the class of tetralins that is tetralin that is substituted by 3-(4-cyclohexylpiperazin-1-yl)propyl and methoxy groups at positions 1 and 5, respectively. It is a sigma 2 (sigma2) receptor agonist (Ki = 0.68 nM) and exhibits antineoplastic and anti SARS-CoV-2 activities. It has a role as an anticoronaviral agent, an antineoplastic agent, an apoptosis inducer and a sigma-2 receptor agonist. It is an aromatic ether, a member of piperazines and a member of tetralins. | [Biological Activity]
High affinity σ 2 receptor agonist (K i values are 0.8 and 15.2 nM for σ 2 and σ 1 receptors respectively) that displays minimal affinity at other receptors. Inhibits electrically evoked twitch in guinea pig bladder and ileum (EC 50 values are 2.62 and 3.96 μ M respectively). Displays antiproliferative and cytotoxic effects in SK-N-SH neuroblastoma and C6 glioma cells. | [in vivo]
PB28 (10.7 mg/mL; intraperitoneal injection; daily; for two weeks; C57BL/6 female mice) treatment inhibits tumor growth in Panc02 tumor burden mice. PB28 also conferres a survival advantage for mice[2]. | Animal Model: | C57BL/6 female mice (10 weeks old) injected with Panc02 cells[2] | | Dosage: | 10.7 mg/mL | | Administration: | Intraperitoneal injection; daily; for two weeks | | Result: | Inhibited tumor growth in Panc02 tumor burden mice.
|
|
|
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|